UNC 0646

CAS No. 1320288-17-2

UNC 0646 ( —— )

Catalog No. M22061 CAS No. 1320288-17-2

UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 52 In Stock
10MG 93 In Stock
25MG 173 In Stock
50MG 308 In Stock
100MG 447 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    UNC 0646
  • Note
    Research use only, not for human use.
  • Brief Description
    UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP).
  • Description
    UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    G9a; GLP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1320288-17-2
  • Formula Weight
    621.9
  • Molecular Formula
    C36H59N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:30 mg/mL (48.24 mM; Need ultrasonic)
  • SMILES
    COC1=C(OCCCN2CCCCC2)C=C2N=C(N=C(NC3CCN(CC3)C3CCCCC3)C2=C1)N1CCCN(CC1)C(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.
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